Research Group Molecular Biophysics

Key publications

  1. Hu, J., Scheidt, T., Thacker, D., Axell, E., Stemme, E., Łapińska, U., Wennmalm, S., Meisl, G., Curk, S., Andreasen, M., Vendruscolo, M., Arosio, P., Šarić, A., Schmit, J. D., Knowles, T. P. J., Sparr, E., Linse, S., Michaels, T. C. T., Dear, A. J. (2026). Structural defects in amyloid-β fibrils drive secondary nucleation. Nat Commun.
  2. *Yu, M., *Gruzinov, A., *Ruan, H., *Scheidt, T., Chowdhury, A., Giofre, S., Mohammed, A., Caria, J., Sauter, P. F., Svergun, D. & Lemke, E. A. (2024) A genetically encoded anomalous SAXS ruler to probe the dimensions of intrinsically disordered proteins. Accepted in Proc. Natl. Acad. Sci. U.S.A.
  3. *Brzezinski, M., Argudo, P. G., Scheidt, T., Yu, M., Lemke, E. A., Michels, J. J. & Parekh, S. H. (2025) Protein specific crowding accelerates aging in protein condensates. Biomacromolecules 26, 4: 2060-2075. Doi:10.1021/acs.biomac.4c00609
  4. *Schneider, M. M., *Scheidt, T., *Priddey, A. J., *Xu, C. K., Hu, M., Meisl, G., Devenish, S. R. A., Dobson, C. M., Kosmoliaptsis, V. & Knowles, T. P. J. (2023) Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum. Biosens. Bioelectron. 228. DOI: 10.1016/j.bios.2023.115196
  5. *Michels, J. J., Brzezinski, M., Scheidt, T., Lemke, E. A., & Parekh, S. H. (2022) Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers. Biomacromolecules 23, 1: 349-364. DOI: 10.1021/acs.biomac.1c01301
  6. *Popper, B., Scheidt, T., & Schieweck, R. (2021) RNA-binding protein dysfunction in neurodegeneration. Essays Biochem. 65, 7: 975-986. DOI: 10.1042/EBC20210024
  7. *Scheidt, T., *Carozza, J. A., Kolbe, C. C., Aprile, F. A., Tkachenko, O., Bellaiche, M. M. J., Meisl, G., Peter, Q. A. E., Herling, T. W., Ness, S., Castellana- Cruz, M., Benesch, J. L. P., Vendruscolo, M., Dobson, C. M., Arosio, P., & Knowles, T. P. J. (2021) The binding of the small heat-shock protein αBcrystallin to fibrils of α-synuclein is driven by entropic forces. Proc. Natl. Acad. Sci. U.S.A. 118, 38. DOI: 10.1073/pnas.2108790118
  8. *Kartanas, T., Levin, A., Toprakcioglu, Z., Scheidt, T., Hakala, T. A., Charmet, J., & Knowles, T. P. J. (2021) Label-Free Protein Analysis Using Liquid Chromatography with Gravimetric Detection. Anal. Chem. 93, 5: 2848-2853. DOI: 10.1021/acs.analchem.0c04149
  9. *Linse, S., Scheidt, T., Bernfur, K., Vendruscolo, M., Dobson, C. M., Cohen, S. I. A., Sileikis, E., Lundqvist, M., Qian, F., O’Malley, T., Bussiere, T., Weinreb, P. H., Xu, C. K., Meisl, G., Devenish, S. R. A., Knowles, T. P. J., & Hansson, O. (2020) Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. Nat. Struct. Mol. Biol. 27, 12: 1125-1133. DOI: 10.1038/s41594-020-0505-6
  10. *Scheidt, T., *Kartanas, T., Peter, Q., Schneider, M. M., Saar, K. L., Müller, T., Challa, P. K., Levin, A., Devenish, S., & Knowles, T. P. J. (2020) Multidimensional protein characterisation using microfluidic post-column analysis. Lab Chip 20, 2663- 2673. DOI: 10.1039/D0LC00219D
  11. *Scheidt, T., Łapińska, U., Kumita, J. R., Whiten, D. R., Klenerman, D., Wilson, M. R., Cohen, S. I. A., Linse, S., Vendruscolo, M., Dobson, C. M., Knowles, T. P. J., & Arosio, P. (2019) Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates. Sci. Adv. 5. DOI: 10.1126/sciadv.aau3112

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